Case Report
Review of Two Siblings with Werner's Syndrome: A Case Report
Table 1
Characteristic features of Werner’s syndrome.
| Diagnostic criteria by Irwin and Ward [3] | Incidence of features reported (%) in Japanese cases () |
| Characteristic habitus and stature | | Short stature (from adolescence) | 86.6 | Slender extremities with stocky trunk | 86.3 | Beak-shaped nose | 75.7 | Premature senility | | Premature grey hair | 86.1 | Premature baldness | 70.0 | Atrophic skin | 85.4 | Weak and high-pitched voice | 76.1 | Arteriosclerosis | 54.0 | Juvenile cataracts | 94.8 | Scleroderma-like changes | | Atrophic skin and subcutaneous tissues | 86.3 | Circumscribed hyperkeratosis | 70.5 | Ulcers over the malleoli of the ankles, Achilles tendon, heels, and toes | 69.5 | Other manifestations | | Tendency to diabetes mellitus | 67.2 | Hypogonadism | 64.2 | Osteoporosis | 54.7 | Localised calcification | 57.4 | Tendency to occur in siblings | 48.7 |
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Data obtained by the authors’ search of MEDLINE and Japanese databases in the years from 1916 to 2002.
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