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Case Reports in Medicine
Volume 2009, Article ID 456402, 4 pages
http://dx.doi.org/10.1155/2009/456402
Case Report

Gastrointestinal Stromal Tumor in Pregnancy: A Case Report

1Department of Obstetrics, Leiden University Medical Center, P.O. Box 9600 (K6-26), 2300 RC Leiden, The Netherlands
2Department of Obstetrics and Gynecology, IJsselland Ziekenhuis, Capelle a/d IJssel, The Netherlands
3Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
4Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands

Received 27 January 2009; Accepted 22 July 2009

Academic Editor: Ron Rabinowitz

Copyright © 2009 S. Scherjon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract and are diagnosed relatively seldom in pregnancy. Case. We describe a remarkable clinical course and long-term outcome, now nine years after first diagnosis, of a massive and metastatic, with a high malignancy grade GIST case, found in and treated from the first trimester of pregnancy onwards. Conclusion. GIST occurring during pregnancy is extremely rare. However, early diagnosis is important for optimal management. The recent better understanding of oncogenesis, the use of immunohistochemistry for differential diagnosis of GISTs, and the use of imatinib mesylate as the treatment of first choice are—as shown in this case—important for care of pregnant women with this type of malignancy.