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Case Reports in Medicine
Volume 2009 (2009), Article ID 469343, 5 pages
http://dx.doi.org/10.1155/2009/469343
Case Report

A Putative Case of Methotrexate-Related Lymphoma: Clinical Course and PET/CT Findings

1Department of Oncology, University of Pittsburgh, Pittsburgh, PA 15213, USA
2Division of Hematology/Oncology, Magee Womens Hospital, University of Pittsburgh Medical Center, 300 Halket Street, Pittsburgh, PA 15213, USA
3Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
4Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA

Received 26 August 2009; Accepted 7 October 2009

Academic Editor: Robert A. Eisenberg

Copyright © 2009 Rachel C. Jankowitz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Anderson, S. Gadalla, L. M. Morton et al., “Population-based study of autoimmune conditions and the risk of specific lymphoid malignancies,” International Journal of Cancer, vol. 125, no. 2, pp. 398–405, 2009. View at Publisher · View at Google Scholar · View at PubMed
  2. G. Starkebaum, “Rheumatoid arthritis and lymphoma: risky business for B cells,” Journal of Rheumatology, vol. 34, no. 2, pp. 243–246, 2007. View at Google Scholar
  3. J. M. Gelfand, D. B. Shin, A. L. Neimann, X. Wang, D. J. Margolis, and A. B. Troxel, “The risk of lymphoma in patients with psoriasis,” Journal of Investigative Dermatology, vol. 126, no. 10, pp. 2194–2201, 2006. View at Publisher · View at Google Scholar · View at PubMed
  4. G. Starkebaum, “Rheumatoid arthritis, methotrexate, and lymphoma: risk substitution, or cat and mouse with Epstein-Barr virus?” Journal of Rheumatology, vol. 28, no. 12, pp. 2573–2575, 2001. View at Google Scholar
  5. M. H. Ellman, H. Hurwitz, C. Thomas, and M. Kozloff, “Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate,” Journal of Rheumatology, vol. 18, no. 11, pp. 1741–1743, 1991. View at Google Scholar
  6. Y. Hoshida, J.-X. Xu, S. Fujita et al., “Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication,” Journal of Rheumatology, vol. 34, no. 2, pp. 322–331, 2007. View at Google Scholar
  7. O. W. Kamel, M. van de Rijn, D. P. LeBrun, L. M. Weiss, R. A. Warnke, and R. F. Dorfman, “Lymphoid neoplasms in patients with rheumatoid arthritis and dermatomyositis: frequency of Epstein-Barr virus and other features associated with immunosuppression,” Human Pathology, vol. 25, no. 7, pp. 638–643, 1994. View at Publisher · View at Google Scholar
  8. O. W. Kamel, M. van de Rijn, L. M. Weiss et al., “Brief report: reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis,” The New England Journal of Medicine, vol. 328, no. 18, pp. 1317–1321, 1993. View at Publisher · View at Google Scholar
  9. J. W. Kennedy, L. K. Wong, B. Kalantarian, L. Turner, and C. W. Hayes, “An unusual presentation of methotrexate-induced B-cell lymphoma of the metacarpophalangeal joint: a case report and literature review,” The Journal of Hand Surgery, vol. 31, no. 7, pp. 1193–1196, 2006. View at Publisher · View at Google Scholar · View at PubMed
  10. H. Kono, S. Inokuma, Y. Matsuzaki et al., “Two cases of methotrexate induced lymphomas in rheumatoid arthritis: an association with increased serum IgE,” Journal of Rheumatology, vol. 26, no. 10, pp. 2249–2253, 1999. View at Google Scholar
  11. G. C. Mackie and J. M. Pohlen, “Methotrexate-induced pulmonary non-Hodgkin lymphoma,” Clinical Nuclear Medicine, vol. 31, no. 5, pp. 272–274, 2006. View at Publisher · View at Google Scholar · View at PubMed
  12. S. H. Nasr, B. Alobeid, J. M. Jacobs, T. E. Peacock, V. D. D'Agati, and G. S. Markowitz, “Methotrexate-associated B-cell lymphoma presenting with acute renal failure and bilateral nephromegaly,” Kidney International, vol. 71, no. 3, pp. 272–275, 2007. View at Publisher · View at Google Scholar · View at PubMed
  13. B. D. Nguyen, M. C. Roarke, and A. E. McCullough, “Methotrexate-induced and Epstein-Barr virus-associated B-cell lymphoma of the spine: MR and PET/CT imaging,” Clinical Nuclear Medicine, vol. 33, no. 3, pp. 208–210, 2008. View at Publisher · View at Google Scholar · View at PubMed
  14. M. Rodrigues, D. Westerman, S. Lade, C. McCormack, and H. M. Prince, “Methotrexate-induced lymphoproliferative disorder in a patient with Sézary syndrome,” Leukemia and Lymphoma, vol. 47, no. 10, pp. 2257–2259, 2006. View at Publisher · View at Google Scholar · View at PubMed
  15. E. Salloum, D. L. Cooper, G. Howe et al., “Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases,” Journal of Clinical Oncology, vol. 14, no. 6, pp. 1943–1949, 1996. View at Google Scholar
  16. M. A. Waldman and J. P. Callen, “Self-resolution of Epstein-Barr virus-associated B-cell lymphoma in a patient with dermatomyositis following withdrawal of mycophenolate mofetil and methotrexate,” Journal of the American Academy of Dermatology, vol. 51, supplement 1, no. 2, pp. S124–S130, 2004. View at Publisher · View at Google Scholar · View at PubMed
  17. E. Baecklund, A. Iliadou, J. Askling et al., “Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis,” Arthritis & Rheumatism, vol. 54, no. 3, pp. 692–701, 2006. View at Publisher · View at Google Scholar · View at PubMed
  18. W.-Y. Au, E. S. K. Ma, C. Choy et al., “Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs,” American Journal of Hematology, vol. 81, no. 1, pp. 5–11, 2006. View at Publisher · View at Google Scholar · View at PubMed
  19. R. Küppers, “B cells under influence: transformation of B cells by Epstein-Barr virus,” Nature Reviews Immunology, vol. 3, no. 10, pp. 801–812, 2003. View at Google Scholar
  20. W.-H. Feng, J. I. Cohen, S. Fischer et al., “Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas,” Journal of the National Cancer Institute, vol. 96, no. 22, pp. 1691–1702, 2004. View at Publisher · View at Google Scholar · View at PubMed