Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature

Table 1

Summary of all reported cases of lactic acidosis associated with lymphoma. (NR: normal range; BP: blood pressure; RR: respiratory rate; P: pulse; T: temperature.)

Reference	Age	Type of lymphoma	Lactate (mmol/L)	Vitals	Directed treatment of lactic acidosis	Chemo	Outcome	Comments
Friedenberg et al. [3]	75	Follicular	5.4	BP NR P104	None	Yes	Died in 2 days
Friedenberg et al. [3]	54	T-cell	12	BP 120/50 P 92	None	Yes	Died in 10 weeks
Friedenberg et al. [3]	54	Diffuse large B-cell	18	BP 96/40 P118	Hemodialysis	Yes	Died in 4 days	Concomitant sepsis (presumed)
He et al. [4]	28	Natural Killer/T-cell	11.2	NR	IV Bicarbonate	Yes	Remission	Died from recurrence after undisclosed period of time
Prikis et al. [5]	65	Large B-cell	18	NR	IV bicarbonate and dialysis	Yes	Remission	Sustained low efficiency dialysis
Dogan et al. [6]	24	Large B-cell	33.0	BP 100/60 P 95 RR18 T 36.7 C	IV Bicarbonate and Hemodialysis	Yes	Died within 10 days
Glasheen and Sorensen [7]	74	Burkitt’s	15.8	NR	None	No	Died in 13 days
Ohtsubo et al. [8]	77	Mantle Cell	26.3	NR	IV Bicarbonate	Yes	Remission
DiComite et al. [9]	64	Large B-cell	9.0	NR	IV Bicarbonate	Yes	Died	Unclear time to death
Sillos et al. [1]	18	Large T-cell	15.4	NR	IV bicarbonate	Yes	Remission	Lymphoma recurred and died in 7 months
Thakur et al. [10]	82	Hodgkin’s	11.5	NR	IV bicarbonate	No	Died in 3 days
Yasin and Hartranft [11]	76	Large B-cell	13.1	NR	None	No	Died in 7 days	Presumed ascending cholangitis. Had two exploratory operations
Durig et al. [12]	71	Non-Hodgkin’s	17.4	BP 120/60 P120	IV Bicarbonate	Yes	Died in 14 days
Scheuleer-Holmes et al. [13]	54	Non-Hodgkin’s	16.4	BP 160/90 P 92 RR 26 T 37.1 C	IV Bicarbonate	Yes	Died within 3 months
Caspar and Oelz [14]	74	Non-Hodgkin’s	14.8	NR	None	No	Died in 2 days
Caspar and Oelz [14]	71	Non-Hodgkin’s	12.2	BP 165/100 P 100	IV Bicarbonate	Yes	Remission	Died in 6 months
Caspar and Oelz [14]	34	Non-Hodgkin’s	23.6	NR	IV Bicarbonate	Yes	Remission	Lactic acidosis occurred after exploratory operation
Doolittle et  al. [15]	19	Diffuse Histiocytic	21.8	BP 90/60 P 120 RR 24, Temp 101 F	IV Bicarbonate	Yes	Died in 5 weeks	Blood cultures negative
Doolittle et  al. [15]	60	Hodgkin’s	16.3	NR	IV Bicarbonate	Yes	Died in 24 days
Vandermolen et al. [16]	32	Non-Hodgkin’s	32	NR	None	Yes	Remission
Johnson and Whelan [17]	21	Non-Hodgkin’s	16.1	NR	IV Bicarbonate	Yes	Died in 14 days	WBC 27,700 and presumed sepsis
Leyden et al. [18]	47	Hodgkin’s	20.0	NR	IV Bicarbonate	Yes	Died within 6 days	Pneumonia
Leyden et al. [18]	61	Non-Hodgkin’s	46.8	NR	IV Bicarbonate	Yes	Died in one day	Gastrointestinal hemorrhage with hemoglobin of 4.0 g/dL
Nadiminti et  al. [19]	30	Hodgkin’s	14	BP 120/80 P106	IV bicarbonate	Yes	Died in 4 weeks
Mintz et al. [20]	65	Histiocytic	21.8	BP 114/66 P 124 RR 32	IV Bicarbonate	No	Died in 4 days
Mintz et al. [20]	34	Histiocytic	14.2	BP 120/75 P100 T 39C	IV Bicarbonate	Yes	Died in 8 days
Mintz et al. [20]	60	Histiocytic	5.9	BP 100/65 P 124 RR 30	None	Yes	Died in 3 weeks
Mintz et al. [20]	58	Histiocytic	4.5	BP 90/60 P 112 RR 50 T 39C	None	Yes	Died in 2 weeks
Scheerer et al. [21]	47	Hodgkin’s	8.8	BP 112/80 P110	IV bicarbonate	Yes	Died in 11 days