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Case Reports in Medicine
Volume 2009, Article ID 757898, 4 pages
http://dx.doi.org/10.1155/2009/757898
Case Report

Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I

1Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
2Department of Neurosurgery, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
3Department of Medical Informatics, Erasmus University Medical Center, 3051 GE Rotterdam, The Netherlands
4Department of Pathology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands

Received 15 July 2009; Accepted 28 October 2009

Academic Editor: Vincenzo Di Lazzaro

Copyright © 2009 Marike L. D. Broekman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neoplasms. The most common brain tumors, found in 15%–20% of NF1 patients, are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. These tumors generally have a benign nature. NF1 patients are predisposed to a 5-fold increased incidence of high-grade astrocytomas, which are usually located in supratentorial regions of the brain. We present an NF1 patient who developed a high-grade astrocytoma in the posterior fossa and discuss possible pathophysiological mechanisms.