Case Report
Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh
Table 5
Naranjo [
8] Causality Scale for Adverse Drug Reactions.
| Question/Scoring-Yes/No/Do not know or unavailable | Case | Case |
| 1 | Are there previous conclusive reports on this reaction? 1/0/0 | 0 | 0 | 2 | Did the adverse event appear after the suspected drug was given? 2/1/0 | 2 | 2 | 3 | Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given? 1/0/0 | 1 | 1 | 4 | Did the adverse reaction appear when the drug was readministered? 2/1/0 | 0 | 0 | 5 | Are there alternative causes that could have caused the reaction? 1/2/0 | | | 6 | Did the reaction reappear when a placebo was given? 1/1/0 | 0 | 0 | 7 | Was the drug detected in any body fluid in toxic concentrations? 1/0/0 | 0 | 0 | 8 | Was the reaction more severe when the dose was increased/ increasing, or less severe when the dose was decreased? 1/0/0 | 1 | 1 | 9 | Did the patient have a similar reaction to the same or similar drugs in any previous exposure? 1/0/0 | 0 | 0 |
| | Total score | 3 | 3 |
|
|
Scoring: 9 definite adverse drug reaction (ADR). 5–8 probable ADR. 1–4 possible ADR. 0 doubtful ADR.
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