Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh
] Causality Scale for Adverse Drug Reactions.
|Question/Scoring-Yes/No/Do not know or unavailable||Case ||Case |
|1||Are there previous conclusive reports on this reaction? 1/0/0||0||0|
|2||Did the adverse event appear after the suspected drug was given? 2/1/0||2||2|
|3||Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given? 1/0/0||1||1|
|4||Did the adverse reaction appear when the drug was readministered? 2/1/0||0||0|
|5||Are there alternative causes that could have caused the reaction? 1/2/0|
|6||Did the reaction reappear when a placebo was given? 1/1/0||0||0|
|7||Was the drug detected in any body fluid in toxic concentrations? 1/0/0||0||0|
|8||Was the reaction more severe when the dose was increased/ increasing, or less severe when the dose was decreased? 1/0/0||1||1|
|9||Did the patient have a similar reaction to the same or similar drugs in any previous exposure? 1/0/0||0||0|
| Total score||3||3|
|Scoring: 9 definite adverse drug reaction (ADR).|
5–8 probable ADR.
1–4 possible ADR.
0 doubtful ADR.