A Novel SCN5A Mutation in a Patient with Coexistence of Brugada Syndrome Traits and Ischaemic Heart Disease

Table 1

Kinetic parameters of wild type and P468L current measured in transiently transfected HEK-293 cells.

	Wild type	P468L
Peak current (at −20 mV)	$-199\pm 35$ pA/pF ($n=11$)	$-213\pm 39$ pA/pF ($n=12$)
Steady-state activation, V1/2	$-30.4\pm 0.6$ mV ($n=14$)	$-31.8\pm 0.6$ mV ($n=10$)
slope, $k$ value	6.2 ± 0.3 mV/e-fold	$6.2\pm 0.5$ mV/e-fold
Steady-state inactivation, V1/2	$-82.0\pm 1.3$ mV ($n=13$)	$-79.2\pm 1.2$ mV ($n=9$)
slope, $k$ value	$6.2\pm 0.2$ mV/e-fold	$5.9\pm 0.3$ mV/e-fold