Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis

Table 1

Reference	Year	Age/Sex	Cystic fibrosis	Days to onset of symptoms	DAT	IgG	C3	Reported presentation	Treatment	Outcome
Thicket et al. [7]	1999	34/Female	Yes	13	+	NR	NR	AA, HU, N	Transfusion, steroids, folate, Pip-Tazo discontinued	Survived
Arndt et al. [4]	2002	29/Male	Yes	11	+	+	+	AA	Transfusion, Pip-Tazo discontinued	Survived
Arndt et al. [4]	2002	37/Male	Yes	12	+	Weak+	Weak+	AA, HU, RS	Transfusion, delayed Pip-Tazo discontinuation	Died
Seder and Zuckerman [3]	2006	33/Female	Yes	7	+	+	+	AA,HU, N	Transfusion, Pip-Tazo discontinued, steroids, immunoglobulin	Survived
Johnson et al.  [8]	1994	46/Male	No	7	+	+	+	AA	NR	NR
Audeh and Wehrli [9]	2002	46/Female	No	7-9	+	+	−	AA	NR	Died
Shirey et al. [10]	2005	62/Female	No	NR	+	+	−	AA, HU, RS, N	Transfusion, Pip-Tazo discontinued	Survived
Mohammed and Greer [11]	2005	58/Male	No	2	+	+	+	AA	Transfusion, Pip-Tazo discontinued	Survived
Shirey et al. [12]	2007	68/female	No	1	+	+	Weak+	AA, HU	Transfusion, Pip-Tazo discontinued	Survived
Garcia Gala et al. [13]	2009	55/male	No	6	+	+	NR	AA	Transfusion, Pip-Tazo discontinued	Survived

AA = Acute anemia
HU = Hemoglobinuria
NR = Not reported
N = Nausea and/or vomiting
Pip-Tazo = Piperacillin-Tazobactam
RS = Respiratory symptoms.