Successful Control of Acute Myelofibrosis with Lenalidomide

Figure 1

(a, b, c) relatively hypercellular marrow with marked fibrosis, abundant atypical megakaryocytes, and scattered immature-appearing cells, (a, b) H&E-stained sections, (c) reticulin stain). (d, e, f) following treatment with lenalidomide, the bone marrow showed patchy hematopoiesis with areas of high and low cellularity ((d) H&E-stained section), decreased numbers of megakaryocytes ((e) H&E-stained section) and a marked reduction in reticulin fibrosis ((f) reticulin stain).