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Case Reports in Medicine
Volume 2010, Article ID 767218, 3 pages
http://dx.doi.org/10.1155/2010/767218
Case Report

Massive Fetomaternal Hemorrhage Caused by an Intraplacental Choriocarcinoma: A Case Report

1Department of Obstetrics and Gynecology, Glostrup Hospital, University of Copenhagen, Nodre Ringvej 37, 2600 Glostrup, Denmark
2Fertility Clinic, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
3Department of Pathology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
4Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Rinvej 75, 2730 Herlev, Denmark

Received 16 November 2009; Accepted 19 January 2010

Academic Editor: Ron Rabinowitz

Copyright © 2010 Anna-Karina Aaris Henningsen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Intraplacental choriocarcinoma is a rare but highly malignant trophoblastic neoplasm. When found near term the risk of maternal metastasis is high because of the late diagnosis. Case. We describe a case of an intraplacental choriocarcinoma diagnosed postpartum after a near-term delivery of a severely anemic infant. A fetomaternal hemorrhage resulted in a hemoglobin concentration in the infant of only 2,1 g/dL. Neither mother nor child showed signs of metastatic disease. The macroscopic examination showed a hydropic placenta weighing more than 1 kilogram. Microscopy showed an intraplacental choriocarcinoma 3 cm in diameter. The tumor had infiltrated the maternal basal plate. Conclusion. Fetomaternal bleeding is a rare form of presentation of choriocarcinoma but its presence should always warrant detailed examination of placenta, mother, and infant.