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Case Reports in Medicine
Volume 2010, Article ID 850402, 3 pages
http://dx.doi.org/10.1155/2010/850402
Case Report

Syndrome of Inappropriate Secretion of Antidiuretic Hormone Cholestasis and Pericardial Effusion Due to Brucellosis Infection: A Case Report

1Department of Gastroenterology, Yüzüncü Yil University School of Medicine, 65200 Van, Turkey
2Department of General Surgery, Yüzüncü Yil University School of Medicine, 65200 Van, Turkey
3Department of Radiology, Yüzüncü Yil University School of Medicine, 65200 Van, Turkey

Received 5 April 2010; Revised 10 July 2010; Accepted 12 July 2010

Academic Editor: J. W. M. Van Der Meer

Copyright © 2010 Ahmet Cumhur Dülger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is an extremely rare complication of infectious diseases. A rare case of brucellosis complicated by syndrome of inappropriate secretion of antidiuretic hormone (SIADH) cholestasis and pericardial involvement is reported. A 27-year-old woman was admitted for fever, abdominal pain, and scleral icterus. Her medical history revealed no recent use of diuretic agents. In addition to cholestasis and elevated liver enzymes, euvolemic hyponatremia, hypouricemia, low plasma osmolality, and high urinary osmolality were also detected. Surrenal and thyroid tests were also within normal range. Echocardiography revealed minimal pericardial effusion with normal cardiac functions. The final diagnosis was SIADH due to Brucellosis. Hyponatremia, cholestasis, and pericardial disease were resolved with effective antibrucellar treatment with streptomycine and doxycycline. After completing treatment of brucellosis, there was not any more evidence of cholestasis and pericardial fluid.