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Case Reports in Medicine
Volume 2011, Article ID 154165, 3 pages
Case Report

Bipolar Affective Disorder and Parkinson's Disease

Department of Neurology, Fachklinikum Brandis, Am Wald, 04821 Brandis, Germany

Received 13 August 2011; Accepted 19 October 2011

Academic Editor: Arya Mitra Sharma

Copyright © 2011 Birk Engmann. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Little is known about comorbidities of bipolar disorder such as Parkinson's disease. A case history and a literature survey indicate that bipolar disorder is linked with or influences Parkinson's disease and vice versa. Underlying mechanisms are poorly understood, and, more importantly, no treatment options are established in such double diagnoses. The few data in comorbid Parkinson cases seem to point to a rapid cycling pattern of bipolar symptoms. With regard to therapeutic intervention, the literature supports pramipexole for treatment of both Parkinson and depressive symptoms in bipolar depression. Lithium, the mood stabilizer of choice for treating manic states, is problematical for use in Parkinson patients because of its side effects. Valproate might be an alternative, especially for treatment of rapid cycling.