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Case Reports in Medicine
Volume 2011, Article ID 202083, 5 pages
http://dx.doi.org/10.1155/2011/202083
Case Report

Fatal Myocarditis in Course of Plasmodium falciparum Infection: Case Report and Review of Cardiac Complications in Malaria

1Scuola di Specializzazione in Malattie Infettive, Università degli Studi di Padova, Via Giustiniani, 35122 Padova, Italy
2Unità Operativa di Malattie infettive e Tropicali, Ospedale S. Bortolo, Viale F. Rodolfi 37, 36100 Vicenza, Italy

Received 10 January 2011; Accepted 21 February 2011

Academic Editor: J. W. M. Van der Meer

Copyright © 2011 Paola Costenaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization (WHO), “World Malaria Report 2008”.
  2. World Health Organization (WHO), “Severe Falciparum Malaria,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 94, pp. 1–90, 2000. View at Google Scholar
  3. A. H. Mohsen, S. T. Green, M. W. McKendrick, and J. N. West, “Myocarditis associated with Plasmodium falciparum malaria: a case report and a review of the literature,” Journal of Travel Medicine, vol. 8, no. 4, pp. 219–220, 2001. View at Google Scholar · View at Scopus
  4. O. Wichmann, T. Löscher, and T. Jelinek, “Fatal malaria in a German couple returning from Burkina Faso,” Infection, vol. 31, no. 4, pp. 260–262, 2003. View at Google Scholar · View at Scopus
  5. D. B. Bethell, P. T. Phuong, C. X. T. Phuong et al., “Electrocardiographic monitoring in severe falciparum malaria,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 90, no. 3, pp. 266–269, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Bruneel, L. Hocqueloux, C. Alberti et al., “The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults,” American Journal of Respiratory and Critical Care Medicine, vol. 167, no. 5, pp. 684–689, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Günther, M. P. Grobusch, H. Slevogt, W. Abel, and G. D. Burchard, “Short communication: myocardial damage in falciparum malaria detectable by cardiac troponin T is rare,” Tropical Medicine and International Health, vol. 8, no. 1, pp. 30–32, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Charoenpan, S. Indraprasit, S. Kiatboonsri, O. Suvachittanont, and S. Tanomsup, “Pulmonary edema in severe falciparum malaria. Hemodynamic study and clinicophysiologic correlation,” Chest, vol. 97, no. 5, pp. 1190–1197, 1990. View at Google Scholar · View at Scopus
  9. J. M. Herrera, “Lesiones cardiacas en la malaria vivax. Estudio de un caso con danos coronario y myocardico,” Archivos del Instituto de Cardiología de México, vol. 30, pp. 26–36, 1960. View at Google Scholar
  10. R. Tripathy, S. Parida, L. Das et al., “Clinical manifestations and predictors of severe malaria in Indian children,” Pediatrics, vol. 120, no. 3, pp. e454–e460, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Wennicke, F. Debierre-Grockiego, D. Wichmann et al., “Glycosylphosphatidylinositol-induced cardiac myocyte death might contribute to the fatal outcome of Plasmodium falciparum malaria,” Apoptosis, vol. 13, no. 7, pp. 857–866, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. S. A. Kim, EU. S. Kim, M. Y. Rhee, S. I. Choi, H. J. Huh, and S. L. Chae, “A case of myocarditis associated with Plasmodium vivax malaria,” Journal of Travel Medicine, vol. 16, no. 2, pp. 138–140, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. P. P. Kumar, C. D. Kumar, F. A. R. Shaik, and S. B. Ghanta, “Myocardial dysfunction in severe falciparum malaria,” Journal of Tropical Pediatrics, vol. 56, no. 1, pp. 67–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. N. J. White, “Loading dose in antimalarial prophylaxis,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 79, no. 5, p. 742, 1985. View at Google Scholar · View at Scopus
  15. S. Ehrhardt, D. Wichmann, C. J. Hemmer, G. D. Burchard, and N. W. Brattig, “Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria,” Tropical Medicine and International Health, vol. 9, no. 10, pp. 1099–1103, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. H. B. Sprague, “The effects of malaria on the heart,” American Heart Journal, vol. 31, no. 4, pp. 426–430, 1946. View at Google Scholar · View at Scopus
  17. D. Franzen, J. M. Curtius, W. Heitz, H. W. Hopp, V. Diehl, and H. H. Hilger, “Cardiac involvement during and after malaria,” Clinical Investigator, vol. 70, no. 8, pp. 670–673, 1992. View at Google Scholar · View at Scopus
  18. N. P. J. Day, T. T. Hien, T. Schollaardt et al., “The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria,” Journal of Infectious Diseases, vol. 180, no. 4, pp. 1288–1297, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Deloron, P. Roux Lombard, P. Ringwald et al., “Plasma levels of TNF-α soluble receptors correlate with outcome in human falciparum malaria,” European Cytokine Network, vol. 5, no. 3, pp. 331–336, 1994. View at Google Scholar · View at Scopus
  20. A. L. Richards, “Tumour necrosis factor and associated cytokines in the host's response to malaria,” International Journal for Parasitology, vol. 27, no. 10, pp. 1251–1263, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Pino, I. Vouldoukis, J. P. Kolb et al., “Plasmodium falciparum-infected erythrocyte adhesion induces caspase activation and apoptosis in human endothelial cells,” Journal of Infectious Diseases, vol. 187, no. 8, pp. 1283–1290, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. S. J. Chakravorty, C. Carret, G. B. Nash, AL. Ivens, T. Szestak, and A. G. Craig, “Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: pathogenic or protective?” International Journal for Parasitology, vol. 37, no. 8-9, pp. 975–987, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Schofield and F. Hackett, “Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites,” Journal of Experimental Medicine, vol. 177, no. 1, pp. 145–153, 1993. View at Publisher · View at Google Scholar · View at Scopus
  24. World Health Organization (WHO), Guidelines for the Treatment of Malaria, World Health Organization, Geneva, Switzerland, 2nd edition, 2010.
  25. N. J. White, “Cardiotoxicity of antimalarial drugs,” Lancet Infectious Diseases, vol. 7, no. 8, pp. 549–558, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. R. J. Maude, K. Plewes, M. A. Faiz et al., “Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?” American Journal of Tropical Medicine and Hygiene, vol. 80, no. 1, pp. 126–132, 2009. View at Google Scholar · View at Scopus
  27. A.-E. Nieman, Q. De Mast, M. Roestenberg et al., “Cardiac complication after experimental human malaria infection: a case report,” Malaria Journal, vol. 8, no. 1, article 277, 2009. View at Publisher · View at Google Scholar
  28. L. T. Cooper, “Myocarditis,” New England Journal of Medicine, vol. 360, no. 15, pp. 1526–1538, 2009. View at Publisher · View at Google Scholar · View at Scopus