Case Reports in Medicine / 2011 / Article / Tab 2

Case Report

Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules

Table 2

Review of the clinical, radiological and pathological features of the published cases of primary pulmonary epithelioid hemangioendothelioma.

Review of the literatureOur case report

Female/male ratio 3 : 1 femaleMale

Mean (SD) age40.1 (17.5) years67 years

SymptomsWeight loss, fatigue, and respiratory symptoms (dyspnoea, chest pain, mild nonproductive cough, and mild haemoptysis)Dyspnoea and dry cough

Chest radiography and computed tomographyUsually multiple bilateral pulmonary nodulesMultiple bilateral pulmonary nodules


Metastatic sitesLymph nodes, liver, bone, skin, serosal membranes, spleen, tonsils, retroperitoneum, kidney and central nervous systemSingle spleen and liver metastatic nodules

Immunohistochemical featuresFactor VIII von Willebrand factor+, CD31+, or CD34+Factor VIII von Willebrand factor+, CD31+, CD34+

5-year survival (%)60%Alive for eight months then lost at the follow up

Obtained with the data from [418].