Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules

Table 2

Review of the clinical, radiological and pathological features of the published cases of primary pulmonary epithelioid hemangioendothelioma.

	Review of the literature	Our case report
Female/male ratio	3 : 1 female	Male
Mean (SD) age	40.1 (17.5) years	67 years
Symptoms	Weight loss, fatigue, and respiratory symptoms (dyspnoea, chest pain, mild nonproductive cough, and mild haemoptysis)	Dyspnoea and dry cough
Chest radiography and computed tomography	Usually multiple bilateral pulmonary nodules	Multiple bilateral pulmonary nodules
PET	Positive	Negative
Metastatic sites	Lymph nodes, liver, bone, skin, serosal membranes, spleen, tonsils, retroperitoneum, kidney and central nervous system	Single spleen and liver metastatic nodules
Immunohistochemical features	Factor VIII von Willebrand factor+, CD31+, or CD34+	Factor VIII von Willebrand factor+, CD31+, CD34+
5-year survival (%)	60%	Alive for eight months then lost at the follow up

Obtained with the data from [4–18].