Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2011, Article ID 432917, 7 pages
Case Report

TFE3 Translocation-Associated Renal Cell Carcinoma Presenting as Avascular Necrosis of the Femur in a 19-Year-Old Patient: Case Report and Review of the Literature

1Department of Urology, Texas Tech University Health Sciences Center, Medical Office Plaza, Lubbock, TX 79415, USA
2Department of Pediatrics, Texas Tech University Health Sciences Center, Lubbock, TX 79430-8115, USA
3Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430-9406, USA

Received 13 June 2011; Accepted 14 July 2011

Academic Editor: Peter Michael Kroisel

Copyright © 2011 T. Nelius et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the United States, renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90–95% of all neoplasms arising from the kidney. According to the National Cancer Institute, 58 240 new cases and 13 040 deaths from renal cancer will occur in 2010. RCC usually occurs in older adults between the ages of 50 and 70 and is rare in young adults and children. We describe a case of a TFE3 translocation-associated RCC in a 19-year-old patient presenting as avascular necrosis of the femur. Due to the rarity of this malignancy, we present this case including a review of the existing literature relative to diagnosis and treatment.