Case Report
Thrombotic Thrombocytopenic Purpura Associated with Mixed Connective Tissue Disease: A Case Report
| | On admission | After 20 days | After 40 days |
| Complete blood count | | | | RBC (×1012/L) | 2.88 | 3.97 | 4.55 | Hemoglobin (g/dL) | 7.8 | 11.5 | 12.4 | Hematocrit (%) | 23.8 | 35 | 39.6 | MCV (fL) | 82.6 | 88 | 87 | MCH (pg) | 27 | 29 | 27 | MCHC (g/dL) | 32.7 | 33 | 31 | RDW (%) | 21.2 | 17.6 | 13.2 | WBC (×109/L) | 9.8 | 5.72 | 7.23 | Platelet (×109/L) | 5.1 | 243 | 312 | Reticulocytes (%) | 8.4 | 1.1 | 0.8 |
| Blood chemistry | | | | AST (IU/L) | 46 | 22 | 21 | ALT (IU/L) | 43 | 29.2 | 31 | GGT (IU/L) | 98 | 230 | 80 | ALP (IU/L) | 98 | 130 | 72 | LDH (IU/L) | 1830 | 365 | 176 | Total bilirubin (mg/dL) | 4.1 | 0.5 | 0.6 | Direct bilirubin (mg/dL) | 2.1 | 0.23 | 0.28 | Indirect bilirubin (mg/dL) | 2 | 0.27 | 0.32 | Glucose (mg/dL) | 128 | 98 | 89 | Urea (mg/dL) | 19 | | | Creatinine (mg/dL) | 0.6 | | | Uric acid (mg/dL) | 3.0 | | | Sodium (mEq/L) | 139 | | | Potassium (mEq/L) | 2.9 | | |
| Hormones | | | | TSH (μU/mL) | 2.72 | | | Free T4 (pg/dL) | 1.08 | | |
| Serology | | | | HBsAg | Negative | | | Anti-HBs | Negative | | | Anti-HBc | Negative | | | Anti-HCV | Negative | | | Anti-HIV | Negative | | | Blood culture | Negative | | |
| Other blood tests | | | | ESR (mm/hr) | 78 | | | PT (s) | 10.2 | | | aPTT (s) | 21.3 | | | Direct Coobs test | Negative | | |
| Urinalysis | | | | Protein | (3+) | | | Leukocyte | (2+) | | | Hemoglobin | (4+) | | | Bilirubin | (1+) | | | Urobilinogen | (2+) | | | Nitrite | (—) | | | Urine culture | negative | | |
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RBC: red blood cells, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration, RDW: red blood cell distribution width, WBC: white blood cells, AST: aspartate aminotransferase, ALT: alanine aminotransferase, ALP: alkaline phosphatase, GGT: gamaglutamil transferase, LDH: lactate dehydrogenase, ESR: erythrocyte sedimentation rate, PT: prothrombin time, ATTP: activated partial thromboplastin time, TSH: Thyroid-stimulating hormone.
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