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Case Reports in Medicine
Volume 2012, Article ID 107894, 4 pages
http://dx.doi.org/10.1155/2012/107894
Case Report

Familial Aggregation of Urinary Tract and Bone Tumors: Searching for a Syndrome

1Department of Orthopedic Surgery, Medical University of Graz, Auenbruggerplatz 5, 8036 Graz, Austria
2Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, 8010 Graz, Austria
3Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria

Received 9 February 2012; Accepted 20 March 2012

Academic Editor: André Mégarbané

Copyright © 2012 Andreas Frings et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Malkin, F. P. Li, L. C. Strong et al., “Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms,” Science, vol. 250, no. 4985, pp. 1233–1238, 1990. View at Google Scholar · View at Scopus
  2. F. P. Li and J. F. Fraumeni, “Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?” Annals of Internal Medicine, vol. 71, no. 4, pp. 747–752, 1969. View at Google Scholar · View at Scopus
  3. T. Frebourg, N. Barbier, Y. X. Yan et al., “Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome,” American Journal of Human Genetics, vol. 56, no. 3, pp. 608–615, 1995. View at Google Scholar · View at Scopus
  4. K. D. Gonzalez, K. A. Noltner, C. H. Buzin et al., “Beyond li fraumeni syndrome: clinical characteristics of families with p53 germline mutations,” Journal of Clinical Oncology, vol. 27, no. 8, pp. 1250–1256, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Le Bihan, C. Moutou, L. Brugieres, J. Feunteun, and C. Bonaiti-Pellie, “ARCAD: a method for estimating age-dependent disease risk associated with mutation carrier status from family data,” Genetic Epidemiology, vol. 12, no. 1, pp. 13–25, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Chompret, L. Brugières, M. Ronsin et al., “P53 germline mutations in childhood cancers and cancer risk for carrier individuals,” British Journal of Cancer, vol. 82, no. 12, pp. 1932–1937, 2000. View at Google Scholar · View at Scopus