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Case Reports in Medicine
Volume 2012, Article ID 163173, 4 pages
Case Report

Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency

1Griffith University School of Medicine and Gold Coast University Hospital, Southport, Gold Coast, QLD 4215, Australia
2Royal Australasian College of Physicians and Royal Melbourne Hospital, Parkville, Melbourne, VIC 3050, Australia
3Pathology Queensland, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4029, Australia
4Department of Cardiology, Gold Coast University Hospital, Griffith University, Southport, Gold Coast, QLD 4215, Australia

Received 11 September 2012; Accepted 16 November 2012

Academic Editor: Christoph Wanner

Copyright © 2012 I. Hamilton-Craig et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bezafibrate therapy has been shown to improve beta-oxidation of fatty acids and to reduce episodes of rhabdomyolysis in patients with carnitine palmitoyltransferase type-2 (CPT2) deficiency. We report the efficacy of fenofibrate in a patient with CPT2 deficiency, in whom beta-oxidation was improved but an episode of rhabdomyolysis nevertheless occurred. This suggests additional methods to avoid rhabdomyolysis in patients with CPT2 deficiency should accompany fibrate therapy, including avoidance of muscular overexertion, dehydration, and heat exposure.