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Case Reports in Medicine
Volume 2012, Article ID 187039, 3 pages
Case Report

Menthol Toxicity: An Unusual Cause of Coma

1Hospital Medicine/Internal Medicine Department, Peninsula Regional Medical Center, Salisbury, MD 2180, USA
2Department of Hospital Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
3Department of Pulmonary, Critical Care and Environmental Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
4Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Department of Hospital Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Mail Code A13, Cleveland, OH 44195, USA

Received 23 August 2012; Revised 29 October 2012; Accepted 29 October 2012

Academic Editor: Michael G. Irwin

Copyright © 2012 Motaz Baibars et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The US Food and Drug Administration (FDA) consider menthol an effective substance, which help in common cold symptoms and labeled to have low toxicity profile. Direct exposure to high menthol amount has been reported in animal; but no studies have been done to show the effect of menthol on long-term use in humans. Up to our knowledge we are reporting a rare case of chronic exposure to significant amount of menthol associated with cutaneous, gastrointestinal and neurological manifestations.