Case Report: Safety and Efficacy of Tocilizumab in a Patient with Rheumatoid Arthritis and Chronic Hepatitis C

Table 1

Liver function, etoricoxib requirement, and arthritis activity at baseline and during treatment with tocilizumab in a 71-year-old female patient with rheumatoid arthritis and HCV Infection.

Parameter	Week 0	Week 2	Week 4	Week 8	Week 12	Week 16	Week 20	Week 24
AST (U/L, normal values <31)	18	28	17	21	16	17	18	20
ALT (U/L, normal values <31)	16	31	19	20	14	13	16	18
GGT (U/L, normal values <32)	20	21	11	12	9	10	7	7
ALP (U/L, normal values <360)	136	155	121	120	133	124	122	139
Total bilirubine (mg/dl, normal values <1.1)	0,61	0,70	0,78	0,70	0,91	0,66	0,56	0,80
Direct bilirubine (mg/dl, normal values <0.5)	0,15	0,18	0,20	0,19	0,23	0,19	0,14	0,21
Etoricoxib 90 mg tablet requirement (numbers/week)	5	1	0	0	0	0	0	0
SDAI (remission <3,3)	59,24	4	1	1	0,5	0,1	0,2	0,2