Extrapulmonary Small Cell Carcinoma of the Anal Canal: A Case Report and Review of the Literature

Table 1

Summary of reported cases of anal canal EPSCC.

Author (yr)	𝑛	Demographic	Metastatic disease at presentation	Treatment	Clinical course
Alcindor et al. (2008) [9]	1	45y M HIV+	y	Chemoradiation, C/E, G-CSF	Primary responded, distant disease progressed, died 6 mo after dx
Doddi et al. (2009) [10]	1	60y F	n	Chemoradiation, C/E	Primary responded, distant disease developed, died 18 mo after dx
Nakahara et al. (1993) [11]	1	48y M HIV+	n	radiation, APR, chemoradiation, C/E, G-CSF	Pelvic local recurrence after surgery, distant disease developed, patient committed suicide 3 mo after surgery
Meyer et al. (2007) [12]	1	41y F	y	Chemoradiation, C/E	Partial response of primary, complete response of liver and lung metastasis, but new bone metastasis developed, died 10 mo after dx
Boman et al. (1983) [8]	13	ns	5y	ns	Median survival 2 mo after dx
			8n	7 APR	6 patients recurred and had median survival of 6 mo after surgery 1 patient with 5 yr survival
				1 radiation	Died 8 mo after treatment

Ns: not specified; APR: abdominoperineal resection; C/E: cisplatin and etoposide; G-CSF: granulocyte colony stimulating factor.