Case Reports in Medicine / 2012 / Article / Tab 1

Case Report

A Case of Persistent Foot Pain in a Neurofibromatosis Type I Patient

Table 1

National Institute of Health diagnostic criteria for neurofibromatosis type I [1]. The criteria are met in an individual if two or more of the features listed are present.

Diagnosis of neurofibromatosis type 1 (NF1)

(1) Six or more café au lait macules >5 mm in greatest diameter in prepubertal individuals and >15 mm in greatest diameter in postpubertal individuals
(2) Two or more neurofibromas of any type or one plexiform neurofibroma
(3) Freckling in the axillary or inguinal regions (Crowe’s sign)
(4) Optic glioma
(5) Two or more Lisch nodules (iris hamartomas)
(6) A distinctive osseous lesion such as sphenoid dysplasia or thinning of long bone cortex with or without pseudoarthrosis
(7) A first-degree relative (parent, sibling, or offspring) with NF1 by the above criteria

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