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Case Reports in Medicine
Volume 2012, Article ID 498518, 3 pages
http://dx.doi.org/10.1155/2012/498518
Case Report

Neurofibromatosis Type 1 Presenting with Plexiform Neurofibromas in Two Patients: MRI Features

Department of Radiology, Sisli Etfal Training and Research Hospital, Sisli, 34360 Istanbul, Turkey

Received 22 July 2012; Accepted 29 August 2012

Academic Editor: Jeffrey M. Weinberg

Copyright © 2012 Ahmet Mesrur Halefoglu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neurofibromatosis type 1 (NF1), also known as peripheral neurofibromatosis or von Recklinghausen’s disease, is one of the most common genetic disorders. It is inherited in an autosomal dominant pattern. Multiple cutaneous neurofibromas are hallmark lesions of NF1. Localized and plexiform neurofibromas of the paraspinal and sacral region are the most common abdominal neoplasms in NF1. Herein, we report two patients with a known history of NF1 presenting with multiple, extensive localized and plexiform neurofibromas. We describe the important distinguishing features of these tumors as seen on magnetic resonance imaging (MRI), including very bright signal intensity and target sign on T2 weighted images.