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Case Reports in Medicine
Volume 2012, Article ID 560942, 3 pages
Case Report

Neurogenic Pulmonary Edema Associated with Underlying Lung Disease after a Breakthrough Seizure

Department of Internal Medicine, Lutheran Medical Center, 150 55th Street, Brooklyn, NY 11209, USA

Received 5 March 2012; Revised 18 June 2012; Accepted 2 July 2012

Academic Editor: Nima Rezaei

Copyright © 2012 Gaurav Dutta and Spiro Demetis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Neurogenic pulmonary edema (NPE) can result from various central nervous system disorders such as brain malignancies, traumatic brain injuries, infections, and seizures. Although the pathogenesis is not completely understood, NPE creates an increase in pulmonary interstitial and alveolar fluid. It has been reported with prolonged seizure activity. Treatment for NPE is largely supportive. If unrecognized, it can lead to hypoxia and respiratory arrest. We report a case of NPE in a middle-aged female patient following a breakthrough seizure in whom an immunological cause for respiratory findings was high on the differential list, based on her past medical history and chronicity of symptoms. Rapid symptomatic and radiological improvement following hospitalization led to the correct diagnosis.