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Case Reports in Medicine
Volume 2012, Article ID 674870, 3 pages
Case Report

Osseous Metaplasia in Castleman's Disease: A Case Report

Pathology Department, Shiraz University of Medical Sciences, Shiraz 71348-53185, Iran

Received 11 September 2011; Revised 3 February 2012; Accepted 5 March 2012

Academic Editor: Valerae O. Lewis

Copyright © 2012 Maral Mokhtari and Perikala Vijayananda Kumar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Castleman's disease is a benign lymphoproliferative disorder. The disease may be localized or multicentric. Three histologic variants are recognized: hyaline vascular, plasma cell, and mixed types. Case. A 20-year-old man presented with large left axillary mass. The histologic examination of the resected mass showed follicular pattern with large nodules of mantle cells arranged concentrically around atrophic and vascularized germinal centers. There was also some benign-appearing bone trabeculae interspersed with lymphoid tissue. The diagnosis of Castleman's disease, hyaline-vascular type with osseous metaplasia, was made.