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Case Reports in Medicine
Volume 2013, Article ID 536231, 3 pages
http://dx.doi.org/10.1155/2013/536231
Case Report

Inclusion-Body Myositis Associated with Alzheimer’s Disease

1New Jersey Neuroscience Institute at JFK Medical Center, 65 James Street, Edison, NJ, USA
2The Neurogenetics Foundation, Cranbury, NJ, USA
3Division of Neuropathology, Department of Pathology and Laboratory Medicine, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA
4Neuroscience Institute, Saint Francis Medical Center, 601 Hamilton Avenue, Trenton, NJ, USA

Received 13 December 2012; Accepted 4 March 2013

Academic Editor: Jahn M. Nesland

Copyright © 2013 Danijela Levacic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sporadic inclusion-body myositis (s-IBM) is a myopathy that is characterized by progressive weakness and muscle pathology demonstrating inflammation and rimmed vacuoles. In addition, similar to the pathology observed in the brains of patients with Alzheimer’s disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. These shared pathologic features have prompted hypotheses suggesting a shared etiology of these two conditions. We report a case of a 73-year-old woman initially diagnosed with s-IBM who later developed Alzheimer’s disease.