Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient

Figure 1

Clinical course of skin ulcers. (a) Skin ulcer with necrotic tissue and cyanotic skin of the left outer ankle 6 months before starting bosentan, (b) at the start of bosentan, and (c) 4 months and (d) 6 months after the administration of bosentan. (e) Skin ulcer of the left hallux 6 months before starting bosentan, (f) after intravenous administration of prostanoids, and at the start of bosentan therapy. (g) Complete healing after 6 months of bosentan therapy. (h) Skin ulcer of the left inner ankle at the start of bosentan, (i) after 4 months (j) and after 6 months of bosentan therapy.

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