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Case Reports in Medicine
Volume 2013, Article ID 792413, 3 pages
Case Report

Amyloid Goiter Associated with Amyloidosis Secondary to Rheumatoid Arthritis

1Department of General Surgery, Istanbul Education and Research Hospital, Turkey
2Department of Internal Medicine, Istanbul Education and Research Hospital, Turkey
3Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Turkey
4Department of Pathology, Istanbul Education and Research Hospital, Turkey

Received 20 July 2013; Accepted 4 November 2013

Academic Editor: Masahiro Kohzuki

Copyright © 2013 Gungor Uzum et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. The most common forms of systemic amyloidosis are primary amyloidosis (PA) of light chains and secondary amyloidosis (SA) caused by chronic inflammatory diseases such as rheumatoid arthritis (RA). Although involvement of the thyroid gland by amyloid is a relatively common phenomenon, clinically significant enlargement of the thyroid owing to amyloid deposition is a rare occurrence. In SA, the deposition of amyloid associated (AA) protein is associated with atrophy of thyroid follicles. The clinical picture of these patients is characterized by rapid, painless thyroid gland enlargement which may be associated with dysphagia, dyspnea, or hoarseness. Thyroid function is not impaired in most cases. Although amyloid goitre secondary to systemic amyloidosis due to chronic inflammatory diseases is relatively common, specifically related to RA is much more uncommon one and it is reported less in the literature. In this report, A 52-old-year female patient with amyloid goiter associated with amyloidosis secondary to rheumatoid arthritis is presented.