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Case Reports in Medicine
Volume 2014, Article ID 351065, 4 pages
Case Report

Breast Cancer Presenting as Paraneoplastic Erythroderma: An Extremely Rare Case

Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece

Received 30 May 2014; Accepted 7 September 2014; Published 11 September 2014

Academic Editor: Ting Fan Leung

Copyright © 2014 Ioannis Protopsaltis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The skin may exhibit the first clinical evidence of a systemic disease and may provide the first clues to a diagnosis in malignancies. Erythroderma is defined as generalized redness and scaling and it is a clinical manifestation of a variety of underlying diseases including, rarely, solid tumors. Breast cancer is associated with a variety of skin paraneoplastic manifestations like acanthosis nigricans, erythromelalgia, thrombotic thrombocytopenic purpura, acrokeratosis paraneoplastica, dermatomyositis, systemic sclerosis, and scleroderma. However, in the literature, the correlation of erythroderma with breast cancer is quite infrequent. Here, we describe a case of a 76-year-old woman who presented with a paraneoplastic manifestation of erythroderma due to breast cancer.