Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2014, Article ID 453874, 8 pages
Case Report

A New Case of Syringocystadenocarcinoma Papilliferum: A Rare Pathology for a Wide-Ranging Comprehension

1Department of Morphology, Surgery and Experimental Medicine, Section of Anatomic Pathology, University of Ferrara and S. Anna University Hospital Via Aldo Moro, 8, 44124 Cona, Ferrara, Italy
2Department of Medical Sciences, Section of Pharmacology and Neuroscience Center, University of Ferrara, Via Aldo Moro, 8, 44124 Cona, Italy
3National Institute of Neuroscience, Italy
4Ri.MED Foundation, Palermo, Italy

Received 30 December 2013; Revised 21 April 2014; Accepted 22 April 2014; Published 15 May 2014

Academic Editor: Jeffrey M. Weinberg

Copyright © 2014 Beatrice Paradiso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a new case of p63/cytokeratin 7 (CK7) positive syringocystadenocarcinoma papilliferum (SCACP), on the shoulder of an 88-year-old man, with superficial dermal infiltration and squamoid differentiation. We describe the 24th case of SCACP, the malignant counterpart of syringocystadenoma papilliferum (SCAP). At the present, we do not know whether SCACP arises from eccrine or apocrine glands because of the contrasting opinions in the literature. Only few histochemical and ultrastructural studies have previously advised that SCACP could arise from pluripotent stem cells. Through our case, we wish to suggest the stem cell-like properties of the syringocystadenocarcinoma papilliferum. This rare neoplasm shows two different patterns of stem cell marker expression in the glandular and squamous components, respectively. For the double phenotype of SCACP, we propose it like an intriguing model to study histogenesis and stem cell properties for more wide-ranging epithelial tumors.