A New Case of Syringocystadenocarcinoma Papilliferum: A Rare Pathology for a Wide-Ranging Comprehension

Table 2

Antigen expression of syringocystadenocarcinoma papilliferum.

Immunohistochemical studies	Normal skin epithelium	Syringocystoadenoma	Syringocystoadenocarcinoma
PCT	Completely positive	Completely positive	Positive outer layer of budding; heterogeneously stained glandular component with accentuation of the membranes
CK5-6	Positive basal and spinous layers	Positive basal layer	Strongly stained transition area from stratified squamous epithelium to neoplasia; heterogeneously and moderately stained squamous solid component and glandular structures
CK7	Negative	Negative	Positive transition area from stratified squamous epitelium to neoplasia; negative squamous solid neoplasia with weak speckled area; positive glandular budding and papillary components
e-cad	Positive epidermidis epithelium; negative keratin layer	Increased pericytoplasmic positivity of the transition area from stratified squamous epitelium to neoplasia with focally negative neoplastic cells	Decreased staining of the neoplastic glands and papillary component and negative infiltrative portion
EMA	Negative	Focally positive	Strongly stained transition area and glandular and papillary components
CEA	Negative	Focally positive	Negative
p63	Almost positive throughout the whole epidermis epithelium, with the strongest expression in basal and suprabasal layers	Positive in discontinuous basal layer	Strongly stained transition area from stratified squamous epithelium to neoplasia; highly positive squamous neoplasm and basal layer of glandular component; moderately positive papillary neoplasia
c-kit	Positive basal layer of epidermis	Positive basal layer of neoplasia	Positive; highly positive basal layer of neoplastic budding; heterogeneously intense-moderate amount of staining of glandular and papillary structures; almost negative, limited occurrence and speckled staining of the squamous-solid component; some positive spindle cells in perineoplastic stroma
S100	Focal positivity of basal layer	Focal positivity	A few positive cells in the squamous component and in perineoplastic stroma
K67	Focal positivity of basal layer	Moderately positive	Completely positive
Nestin	Negative; positive-endothelial cells and hair follicles	Negative; positive-endothelial cells and hair follicles	A few positive cells in the squamous component and in perineoplastic stroma
CD133	Almost negative; very rare positivity in the granular layer epidermis	Moderately positive	Aberrant cytoplasmic overexpression, more intense in the glandular and papillary components
CD44	Transmembrane positivity with the strongest expression in basal layers	Faintly positive	Increasing of pericytoplasmic expression in the neoplastic squamous component; almost unstained glandular component; positivity in the stroma