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Case Reports in Medicine
Volume 2014, Article ID 473297, 4 pages
http://dx.doi.org/10.1155/2014/473297
Case Report

Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm

1Department of Hematology/Oncology/BMT, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA
2Department of Hematology/Oncology/BMT, Nationwide Children’s Hospital, The Ohio State University, 700 Children’s Drive, Columbus, OH 43205, USA
3Department of Pathology, Nationwide Children’s Hospital, The Ohio State University, 700 Children’s Drive, Columbus, OH 43205, USA

Received 3 December 2013; Accepted 15 February 2014; Published 18 March 2014

Academic Editor: Werner Rabitsch

Copyright © 2014 Gary M. Woods et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by hyperproliferation of hematologic cell lines and have been associated with tyrosine kinase JAK2-V617F mutations. Secondary acute myeloid leukemia (sAML) is a known complication of JAK2-V617F+ MPNs and bears a poor prognosis. Although the evolution of a JAK2-V617F+ MPN to a mixed-lineage leukemia has been reported in the pediatric population, no evolutions into sAML have been described. We present a case of a one-year-old girl diagnosed with JAK2-V617F+ MPN with evolution into sAML. Despite initial morphologic remission, she eventually relapsed and succumbed to her disease.