Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2014, Article ID 545490, 4 pages
http://dx.doi.org/10.1155/2014/545490
Case Report

“Dancing Eye Syndrome” Secondary to Opsoclonus-Myoclonus Syndrome in Small-Cell Lung Cancer

1Department of Thoracic Oncology, Pleural Diseases, and Interventional Pulmonology, AP-HM-Hôpital Nord, Chemin des Bourrely, 13326 Marseille Cedex 20, France
2Aix-Marseille University, 13005 Marseille, France
3Department of Respiratory Medicine, University Hospitals Galway, Galway, Ireland

Received 20 September 2013; Accepted 2 March 2014; Published 23 March 2014

Academic Editor: Hitoshi Okamura

Copyright © 2014 S. Laroumagne et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Among paraneoplastic neurologic disorders (PND), opsoclonus-myoclonus syndrome, so-called “dancing eye syndrome,” is a rare disorder combining multivectorial eye movements, involuntary multifocal myoclonus, and cerebellar ataxia. Although several paraneoplastic antibodies against postsynaptic or cell-surface antigens have been reported, usually most patients are serum antibody negative. We report a 65-year-old patient with opsoclonus-myoclonus syndrome revealing a small-cell lung carcinoma. If serologic antineuronal anti-body screening was negative, autoantibodies against glutamic acid decarboxylase (anti-GAD) were positive. Despite the specific anticancer treatment and high dose corticosteroids, the patient developed a severe and progressive encephalopathy and died 10 days later.