Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2014, Article ID 612496, 5 pages
http://dx.doi.org/10.1155/2014/612496
Case Report

Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma

The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK

Received 19 February 2014; Accepted 30 June 2014; Published 8 July 2014

Academic Editor: Sarkis Meterissian

Copyright © 2014 J. Martin-Liberal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Ferrari, I. Sultan, T. T. Huang et al., “Soft tissue sarcoma across the age spectrum: a population-based study from the surveillance epidemiology and end results database,” Pediatric Blood and Cancer, vol. 57, no. 6, pp. 943–949, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Thanopoulou and I. Judson, “Hormonal therapy in gynecological sarcomas,” Expert Review of Anticancer Therapy, vol. 12, no. 7, pp. 885–894, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. E. D'Angelo and J. Prat, “Uterine sarcomas: a review,” Gynecologic Oncology, vol. 116, no. 1, pp. 131–139, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Koivisto-Korander, R. Butzow, A. Koivisto, and A. Leminen, “Immunohistochemical studies on uterine carcinosarcoma, leiomyosarcoma, and endometrial stromal sarcoma: expression and prognostic importance of ten different markers,” Tumor Biology, vol. 32, no. 3, pp. 451–459, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. C. Chu, G. Mor, C. Lim, W. Zheng, V. Parkash, and P. E. Schwartz, “Low-grade endometrial stromal sarcoma: hormonal aspects,” Gynecologic Oncology, vol. 90, no. 1, pp. 170–176, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. X. Cheng, G. Yang, K. M. Schmeler et al., “Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy,” Gynecologic Oncology, vol. 121, no. 2, pp. 323–327, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Pink, T. Lindner, A. Mrozek et al., “Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma: Single center experience with 10 cases and review of the literature,” Gynecologic Oncology, vol. 101, no. 3, pp. 464–469, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. E. Akhan, E. Yavuz, A. Tecer et al., “The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study,” Gynecologic Oncology, vol. 99, no. 1, pp. 36–42, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. J. Ioffe, A. J. Li, C. S. Walsh et al., “Hormone receptor expression in uterine sarcomas: prognostic and therapeutic roles,” Gynecologic Oncology, vol. 115, no. 3, pp. 466–471, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Spano, J.-C. Soria, M. Kambouchner et al., “Long-term survival of patients given hormonal therapy for metastatic endometrial stromal sarcoma,” Medical Oncology, vol. 20, no. 1, pp. 87–93, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Dahhan, G. Fons, M. R. Buist, F. J. W. ten Kate, and J. van der Velden, “The efficacy of hormonal treatment for residual or recurrent low-grade endometrial stromal sarcoma. A retrospective study,” European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 144, no. 1, pp. 80–84, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Leunen, M. Breugelmans, P. de Sutter, C. Bourgain, and J. J. Amy, “Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole,” Gynecologic Oncology, vol. 95, no. 3, pp. 769–771, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Shoji, K. Oda, S. Nakagawa et al., “Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report,” Medical Oncology, vol. 28, no. 3, pp. 771–774, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Reich and S. Regauer, “Hormonal therapy of endometrial stromal sarcoma,” Current Opinion in Oncology, vol. 19, no. 4, pp. 347–352, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Amant, A. Coosemans, M. Debiec-Rychter, D. Timmerman, and I. Vergote, “Clinical management of uterine sarcomas,” The Lancet Oncology, vol. 10, no. 12, pp. 1188–1198, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. K. A. Brown, N. U. Samarajeewa, and E. R. Simpson, “Endocrine-related cancers and the role of AMPK,” Molecular and Cellular Endocrinology, vol. 366, no. 2, pp. 170–179, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Attard, J. Richards, and J. S. de Bono, “New strategies in metastatic prostate cancer: targeting the androgen receptor signaling pathway,” Clinical Cancer Research, vol. 17, no. 7, pp. 1649–1657, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. I. E. Smith and M. Dowsett, “Aromatase inhibitors in breast cancer,” The New England Journal of Medicine, vol. 348, no. 24, pp. 2431–2442, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Nabholtz, A. Buzdar, M. Pollak et al., “Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial,” Journal of Clinical Oncology, vol. 18, no. 22, pp. 3758–3767, 2000. View at Google Scholar · View at Scopus
  20. J. Bonneterre, B. Thürlimann, J. F. R. Robertson et al., “Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the tamoxifen or arimidex randomized group efficacy and tolerability study,” Journal of Clinical Oncology, vol. 18, no. 22, pp. 3748–3757, 2000. View at Google Scholar · View at Scopus
  21. H. Mouridsen, M. Gershanovich, Y. Sun et al., “Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the international letrozole breast cancer group,” Journal of Clinical Oncology, vol. 19, no. 10, pp. 2596–2606, 2001. View at Google Scholar · View at Scopus
  22. D. Mauri, N. Pavlidis, N. P. Polyzos, and J. P. A. Ioannidis, “Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis,” Journal of the National Cancer Institute, vol. 98, no. 18, pp. 1285–1291, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Schiff, S. A. Massarweh, J. Shou et al., “Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance,” Clinical Cancer Research, vol. 10, no. 1, part 2, pp. 331S–336S, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. S. R. D. Johnston, C. Arteaga, E. Winer, M. Dowsett, R. Kumar, and S. Come, “Clinical efforts to combine endocrine agents with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of rapamycin in breast cancer,” Clinical Cancer Research, vol. 12, no. 3, part 2, pp. 1061s–1068s, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. H. J. Burstein, “Novel agents and future directions for refractory breast cancer,” Seminars in Oncology, vol. 38, supplement 2, pp. S17–S24, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Baselga, M. Campone, M. Piccart et al., “Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer,” The New England Journal of Medicine, vol. 366, no. 6, pp. 520–529, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Thomas, F. Lamoureux, C. Crafter, B. R. Davies, E. Beraldi, and L. Fazli, “Synergistic targeting of PI3K/AKT pathway and androgen receptor axis significantly delays castration-resistant prostate cancer progression in vivo,” Molecular Cancer Therapeutics, vol. 12, no. 11, pp. 2342–2355, 2013. View at Google Scholar
  28. E. A. Eisenhauer, P. Therasse, J. Bogaerts et al., “New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1),” European Journal of Cancer, vol. 45, no. 2, pp. 228–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Choi, C. Charnsangavej, S. C. Faria et al., “Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria,” Journal of Clinical Oncology, vol. 25, no. 13, pp. 1753–1759, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Reichardt, “The treatment of uterine sarcomas,” Annals of Oncology, vol. 23, supplement 10, pp. x151–x157, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. J. K. Chan, N. M. Kawar, J. Y. Shin et al., “Endometrial stromal sarcoma: a population-based analysis,” The British Journal of Cancer, vol. 99, no. 8, pp. 1210–1215, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. B. M. Seddon and R. Davda, “Uterine sarcomas—recent progress and future challenges,” European Journal of Radiology, vol. 78, no. 1, pp. 30–40, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. R. L. Yamnik and M. K. Holz, “mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation,” FEBS Letters, vol. 584, no. 1, pp. 124–128, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. R. L. Yamnik, A. Digilova, D. C. Davis, Z. N. Brodt, C. J. Murphy, and M. K. Holz, “S6 kinase 1 regulates estrogen receptor α in control of breast cancer cell proliferation,” Journal of Biological Chemistry, vol. 284, no. 10, pp. 6361–6369, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. G. D. Demetri, S. P. Chawla, I. Ray-Coquard et al., “Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy,” Journal of Clinical Oncology, vol. 31, no. 19, pp. 2485–2492, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. S. P. Chawla, A. P. Staddon, L. H. Baker et al., “Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas,” Journal of Clinical Oncology, vol. 30, no. 1, pp. 78–84, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. S. H. Tirumani, J. P. Jagannathan, K. O'Regan, K. W. Kim, K. M. Krajewski, and N. H. Ramaiya, “Molecular targeted therapies in non-GIST soft tissue sarcomas: what the radiologist needs to know,” Cancer Imaging, vol. 13, no. 2, pp. 197–211, 2013. View at Publisher · View at Google Scholar · View at Scopus