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Case Reports in Medicine
Volume 2014, Article ID 902818, 5 pages
http://dx.doi.org/10.1155/2014/902818
Case Report

Pulmonary Phaeohyphomycosis Caused by Phaeoacremonium in a Kidney Transplant Recipient: Successful Treatment with Posaconazole

1The Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Renal Division/Campus Box 8126, St. Louis, MO 63110, USA
2Barnes-Jewish Hospital, Center for Outpatient Health, 4901 Forest Park Avenue, 5th Floor, St. Louis, MO 63108, USA
3Department of Pathology & Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8118, St. Louis, MO 63110, USA

Received 18 December 2013; Revised 3 March 2014; Accepted 21 March 2014; Published 14 May 2014

Academic Editor: Samy S. Iskandar

Copyright © 2014 Saivaralaxmi Monaganti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a rare case of pulmonary phaeohyphomycosis in a 49-year-old woman 6 years after kidney transplantation. She presented with dyspnea, cough, and fatigue. Her chest CT scan revealed nodular opacities in the right upper lung. A fine needle aspirate biopsy culture yielded Phaeoacremonium and surgical pathology of the biopsy showed chronic inflammation. We successfully treated her with posaconazole and managed drug interactions between posaconazole and tacrolimus. This is the second reported case of biopsy-proven pulmonary infection by Phaeoacremonium in a kidney transplant recipient and successfully treated with posaconazole.