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Case Reports in Medicine
Volume 2015, Article ID 203936, 3 pages
Case Report

Baclofen-Induced Encephalopathy in End Stage Renal Disease

Department of Medicine, Temple University Hospital, Philadelphia, PA, USA

Received 6 June 2015; Accepted 22 July 2015

Academic Editor: W. Zidek

Copyright © 2015 Andrew Meillier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Baclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for spasticity and chronic hiccups. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in administering baclofen to patients with decreased renal function. We present a patient with end stage renal disease on hemodialysis with recent baclofen ingestion who presented with toxic encephalopathy that was resolved with additional dialysis sessions.