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Case Reports in Medicine
Volume 2015 (2015), Article ID 217951, 4 pages
Case Report

Acute Cyanide Poisoning: Hydroxocobalamin and Sodium Thiosulfate Treatments with Two Outcomes following One Exposure Event

Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA

Received 24 July 2015; Revised 27 September 2015; Accepted 28 September 2015

Academic Editor: Bruno Megarbane

Copyright © 2015 Andrew Meillier and Cara Heller. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cyanide is rapidly reacting and causes arrest of aerobic metabolism. The symptoms are diffuse and lethal and require high clinical suspicion. Remediation of symptoms and mortality is highly dependent on quick treatment with a cyanide antidote. Presently, there are two widely accepted antidotes: sodium thiosulfate and hydroxocobalamin. These treatments act on different components of cyanide’s metabolism. Here, we present two cases resulting from the same source of cyanide poisoning and the use of both antidotes separately used with differing outcomes.