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Case Reports in Medicine
Volume 2015, Article ID 432910, 4 pages
http://dx.doi.org/10.1155/2015/432910
Case Report

Parkinsonism and Sjögren’s Syndrome: A Fortuitous Association or a Shared Immunopathogenesis?

1Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, Beb Souika, 1016 Tunis, Tunisia
2Faculty of Medicine of Tunis, Tunisia
3El Manar University, Tunisia

Received 24 February 2015; Revised 3 May 2015; Accepted 19 May 2015

Academic Editor: Indraneel Bhattacharyya

Copyright © 2015 Mariem Kchaou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The Sjögren Syndrome (SS) can include various manifestations of central nervous system impairment. Extrapyramidal signs are known to be very rare and unusually discovered on early onset in this pathology. Observation. A 46-year-old woman with a history of progressive Parkinsonism for 6 years and a normal brain magnetic resonance imaging was partially improved with levodopa therapy. The later discovery of a sicca syndrome led to performing of further investigations, which revealed the presence of anti-SSA antibodies and a sialoadenitis of grade 4 according to Chisholm’s classification on labial salivary gland biopsy. The diagnosis of primary SS was established and the adjunction of corticotherapy has remarkably improved Parkinson’s signs without use of other immunosuppressive agents. Conclusion. Based on these findings, we discuss the hypothesis of either a causal link between SS and Parkinsonism or a fortuitous association of two distinct pathologies with or without a shared immunopathogenesis.