Association between Neurofibromatosis Type 1 and Breast Cancer: A Report of Two Cases with a Review of the Literature

Table 1

Summary of previously reported NF1 patients with breast cancer.

Author	Age (yr)	Family history of breast cancer	Gene mutation	Stage	Molecular subtype	Characteristics
Brasfield and Das Gupta [8]	5 patients
McMillan and Edwards [9]	27	NA	NA	NA	NA
Hiraide et al. [10]	32	NA	NA	NA	NA
el-Zawahry et al. [11]	2 patients
Vilar Sanchis and Vazquez Albaladejo [12]	1 patient
Hollo way et al. [13]	68	NA	NA	IIA	NA	Male
Nakamura et al. [14]	49	NA	NA	NA	NA
Murayama et al. [15]	66	NA	NA	IIA	NA
Ceccaroni et al. [16]	66	Daughter	NA	NA	NA
Satgé et al. [17]	23	4 aunts	NA	NA	NA
Güran and Safali [18]	23	Mother	NA	NA	NA
	52	Daughter	NA	NA	NA
Posada and Chakmakjian [19]	74	No	NA	IIA	NA
Kawawa et al. [20]	66	No	NA	IIB	Luminal	Paget’ disease
Natsiopoulos et al. [21]	60	No	NA	IIB		Metaplastic carcinoma
Hasson et al. [22]	49	No	NA	IB	Luminal
Invernizzi et al. [23]	60	NA	NA	IA	Luminal
Alamsamimi et al. [24]	51	Sister	NA	IIA	Luminal	Synchronous bilateral breast cancer
Salemis et al. [25]	59	No	NA	IIB	Luminal
Bhargava et al. [26]	58	NA	NA	NA	NA
Takeuchi et al. [27]	76	NA	NA	IIA	NA	Metachronous contralateral breast cancer
Zhou et al. [28]	48	NA	NA	IA	Luminal
Campos et al. [29]	35	Mother	NA	NA	Nonluminal
	40	Daughter	BRCA1	IV	NA
Cheuk et al. [30]	42	NA	NA	NA	NA
Jinkala et al. [31]	69	NA	NA	NA	NA
Nogimori et al. [32]	1 patient
Vivas et al. [33]	53	NA	NA	IV	HER2	Metaplastic carcinoma
Lakshmaiah et al. [34]	55	No	NA	IIB	Luminal	Male
Chaudhry et al. [35]	46	No	NA	IIIA	HER2	Metaplastic carcinoma
Da Silva et al. [36]	54	No	NA	IA	HER2
Jeon et al. [37]	21	No	No	IIB	Luminal
	30	No	NA	IIA	Luminal	Metachronous contralateral breast cancer
Khalil et al. [38]	39	NA	NA	IIIA	Luminal
Zöller et al. [2]	2 breast cancers in 70 NF1 patients (2.8%)
Walker et al. [3]	5 breast cancers in 448 NF1 patients (1.1%)
Sharif et al. [4]	14 breast cancers in 304 NF1 patients (4.6%)
Madanikia et al. [5]	4 breast cancers in 126 NF1 patients (3.2%)
Wang et al. [6]	15 breast cancers in 76 NF1 patients (19.7%)
Seminog and Goldacre [7]	52 breast cancers in 3855 NF1 patients (1.3%)

NF1: neurofibromatosis type 1; NA: not assessable; luminal: estrogen receptor (ER) or progesterone receptor (PR) positive; nonluminal: ER and PR negative; HER2: ER and PR negative and human epidermal growth factor receptor 2 (HER2) positive.
Neurofibromatosis patient.
Mother-daughter relationship.