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Case Reports in Medicine
Volume 2015, Article ID 545603, 5 pages
Case Report

Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis

1Dermatology Department, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, Portugal
2Pathological Anatomy Department, Hospital de Braga, Sete Fontes, São Victor, 4710-243 Braga, Portugal

Received 8 September 2014; Accepted 17 January 2015

Academic Editor: Jeffrey M. Weinberg

Copyright © 2015 Catarina Araújo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.