Multiglandular Hormone Deficiency in a Patient with Systemic Capillary Leak Syndrome

Table 1

Hormone, hormone-binding globulin, and immunoglobulin levels of the described patient at the indicated time points after first admission to our hospital due to a systemic capillary leak attack. For comparison, commonly observed hormonal changes in critically ill patients are shown.

Parameter	kDa	Range	Day 2	Day 12	Day 23	Week 8	Week 11	Week 18	Month 10	Critical illness (acute)	Critical illness (prolonged)
IgG (µmol/L)	144	55.5–125	46.9	—	83.3	109.9	—	52.4	49
IgA (µmol/L)	160	5.6–28	2.4	—	4.1	4.8	—	3.9	4.3
IgM (µmol/L)	971	0.6–2.6	0.4	—	0.7	0.8	—	0.5	0.6
TSH (mU/L)	28	0.3–4	6.1	—	—	—	2.01	2.03	2.41	→ (↓)	↓
fT3 (pmol/L)	0.65	3.5–6.6	5.8	—	—	—	—	—	6.1	↓	↓
fT4 (pmol/L)	0.8	10.3–24.5	13.7	—	—	—	—	—	17.4	→ (↓)	→ (↓)
LH (U/L)	24	1.2–8	13.5	—	13.8	—	—	—	7.4	↑	↓
FSH (U/L)	32	1–9	14.4	—	15.0	—	—	—	15.3	→ (↑)	↓
ACTH (pmol/L)	4.5	2.2–15.4	5.5	—	—	—	17.8	16.1	21.6	↑	↓
hGH (nmol/L)	22	0–360	16.3	—	—	—	—	—	47	↑	(↑)
IGF-1 (nmol/L)	7.6	9.2–38	12.9	—	—	—	—	—	25	↓	↓
Prolactin (mU/L)	22.9	30–350	261	—	—	—	—	—	—	↑	(↓)
Testosterone (nmol/L)	0.29	12–35	3.8	—	14.3	—	10.8	10.0	14	↓	↓
Free androgen index (%)	—	>22	5.2	—	17.7	—	17.2	12.4	30	↓	↓
Cortisol after ACTH stimulation (nmol/L)	0.36	635–1560	333.8	—	460.7	474.5	430.4	—	422	↑↑	↑↑
DHEAS (µmol/L)	0.37	0.95–11.7	0.54	—	—	1.63	—	1.64	—	↓	↓↓
Transcortin (µmol/L)	52	0.8–1.1	—	0.6	0.8	0.7	—	—	—	↓	↓
TBG (nmol/L)	54	260–500	—	—	250	330	—	—	—	↓	↓
SHBG (nmol/L)	86	10–50	70.5	—	81.3	—	58.2	58.3	47	↓	↓
Aldosterone (pmol/L)	0.36	55–416	—	368	512	867	—	304	450	→↑
Plasma renin (mU/L)	42		—	309	245	1250	—	137	202	↑↑