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Case Reports in Medicine
Volume 2016, Article ID 1298375, 3 pages
Case Report

Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis

Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, India

Received 28 July 2016; Revised 26 October 2016; Accepted 3 November 2016

Academic Editor: Masahiro Kohzuki

Copyright © 2016 Geetha Narayanan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Leukemia cutis (LC) is defined as infiltration of the skin by leukemic cells resulting in clinically recognizable cutaneous lesions. It is common in congenital leukemia and acute myeloid leukemia. However, LC has rarely been reported with mixed phenotypic acute leukemia (MPAL). We report the case of a lady who presented with erythematous papular and nodular lesions all over the body. Skin biopsy showed leukemic infiltration and bone marrow aspiration showed MPAL of the T/myeloid with monocytic differentiation lineage. This is the first report of an adult patient with MPAL of the T/myeloid with monocytic differentiation type presenting with leukemia cutis. She was started on chemotherapy with Hyper-CVAD. There is complete resolution of the skin lesions and she has achieved bone marrow remission after the first cycle of chemotherapy.