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Case Reports in Medicine
Volume 2016 (2016), Article ID 3489046, 5 pages
http://dx.doi.org/10.1155/2016/3489046
Case Report

IL-6-Producing, Noncatecholamines Secreting Pheochromocytoma Presenting as Fever of Unknown Origin

1Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
2Department of Radiological Sciences, Oncology and Pathology, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy

Received 25 January 2016; Revised 11 June 2016; Accepted 17 July 2016

Academic Editor: Christian Koch

Copyright © 2016 Marco Ciacciarelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fever of unknown origin (FUO) can be an unusual first clinical manifestation of pheochromocytoma. Pheochromocytomas are tumors that may produce a variety of substances in addition to catecholamines. To date, several cases of IL-6-producing pheochromocytomas have been reported. This report describes a 45-year-old woman with pheochromocytoma who was admitted with FUO, normal blood pressure levels, microcytic and hypochromic anemia, thrombocytosis, hyperfibrinogenemia, hypoalbuminemia, and normal levels of urine and plasma metanephrines. After adrenalectomy, fever and all inflammatory findings disappeared.