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Case Reports in Medicine
Volume 2016, Article ID 7649510, 4 pages
Case Report

Systemic Light Chain Amyloidosis Mimicking Rheumatic Disorders

1Department of Hematology/Oncology, Allegheny Health Network, 320 East North Avenue, Pittsburgh, PA 15212, USA
2Department of Internal Medicine, The Mary Imogene Bassett Hospital, One Atwell Road, Cooperstown, NY 13326, USA
3Lupus Center of Excellence, Allegheny Health Network, 4800 Friendship Avenue, Suite 2600, North Tower, Pittsburgh, PA 15224, USA

Received 6 July 2016; Revised 26 September 2016; Accepted 28 September 2016

Academic Editor: Mamede de Carvalho

Copyright © 2016 Rohit R. Rao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Secondary amyloidosis can complicate chronic inflammatory autoimmune diseases. However, the clinical findings of primary amyloidosis may mimic those of primary rheumatologic disorders. We present the case of a 53-year-old woman who presented with dystrophic nail changes, dry eyes, bilateral carpal tunnel syndrome, Raynaud’s phenomenon, and high titer positive nucleolar pattern antinuclear antibody. She was initially misdiagnosed as having Undifferentiated Connective Tissue Disease (UCTD). On further workup, she was eventually diagnosed with lambda light chain systemic amyloidosis by abdominal fat pad biopsy. Her symptoms completely resolved after autologous stem cell transplantation. With this case, we would like to highlight the similarities in the clinical features between light chain amyloidosis and rheumatological disorders. We would also like to emphasize the importance of the prompt recognition of the clinical features of amyloidosis which are crucial to triggering appropriate diagnostic procedures, since early diagnosis is a key to improving outcomes in this disease with an otherwise poor prognosis.