B-Cell Chronic Lymphocytic Leukemia with 11q22.3 Rearrangement in Patient with Chronic Myeloid Leukemia Treated with Imatinib

Figure 2

The patient’s bone marrow cell culture. (a) Metaphase staining by Giemsa contains alteration chromosomes 8 and 11 from translocation t(?8;11)(q?13;q22) (indicated by arrows). (b) FISH results with ATM/CEP11 probe on the same metaphase showed rearrangement in 11q22.3 band (two smaller red signals and one normal signal). (c) Interphase FISH results with specific probe ATM/CEP11 reveal three signals (one normal and two smaller signals) for ATM and two typical signals for CEP 11.