Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2017, Article ID 3512353, 3 pages
Case Report

Recovery from Cogwheel Rigidity and Akinesia and Improvement in Vibration Sense and Olfactory Perception following Removal of an Epoxy-Oleic Acid DNA Adduct

1Breakspear Medical Group, Hemel Hempstead, Hertfordshire, UK
2Acumen, P.O. Box 129, Tiverton, Devon, UK
3Barts and the London School of Medicine, Queen Mary University of London and the William Harvey Research Institute, London, UK
4Department of Medicine, Imperial College London, London, UK

Correspondence should be addressed to Basant K. Puri;

Received 2 July 2017; Revised 26 September 2017; Accepted 3 October 2017; Published 18 October 2017

Academic Editor: Mamede de Carvalho

Copyright © 2017 Jean A. Monro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The epoxy fatty acid cis-12,13-epoxy-oleic acid, which acts as a DNA adduct, may be generated during long-term storage of many seed oils, including those used in cooking, with frying oils and fried foods being a major source in the modern human diet. Removal of this epoxy fatty acid from the locus of the N-formyl peptide receptors was associated with recovery from cogwheel rigidity and akinesia as well as with improvement in vibration sense and olfactory perception.