Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2017, Article ID 3769074, 3 pages
Case Report

Severe Murine Typhus Presenting with Acalculous Cholecystitis: A Case Report and Literature Review

1Internal Medicine Department, Infectious Diseases Unit, University Hospital of Heraklion, Heraklion, Crete, Greece
2School of Medicine, European University Cyprus, Nicosia, Cyprus
3Department of Medicine, University of Crete, Heraklion, Crete, Greece

Correspondence should be addressed to Constantinos Tsioutis; moc.liamg@situoistsok

Received 22 December 2016; Accepted 27 March 2017; Published 4 April 2017

Academic Editor: Simone Cesaro

Copyright © 2017 Nikolaos Spernovasilis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 54-year-old otherwise healthy male, who was being evaluated for prolonged fever, developed clinical and ultrasonographic signs compatible with acute acalculous cholecystitis. Diagnosis of murine typhus was confirmed by serology and the patient was treated with doxycycline. He improved rapidly and all clinical and laboratory abnormalities returned to normal. The present case dictates that knowledge of the local epidemiology and keeping a high index of clinical suspicion can help recognize uncommon manifestations of murine typhus, in order to treat appropriately and avoid unnecessary investigations and interventions.