Case Reports in Medicine
Volume 2017, Article ID 9896210, 3 pages
https://doi.org/10.1155/2017/9896210
Implications of Antiphospholipid and Antineutrophilic Cytoplasmic Antibodies in the Context of Postinfectious Glomerulonephritis
1Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
2Department of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, USA
Correspondence should be addressed to Lavjay Butani; ude.sivadcu@inatubl
Received 5 January 2017; Accepted 22 January 2017; Published 1 February 2017
Academic Editor: Rolando Cimaz
Copyright © 2017 Daniel Leifer and Lavjay Butani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
While antineutrophil cytoplasmic antibody (ANCA) positivity has been documented in some patients with postinfectious glomerulonephritis (PIGN) and is associated with more severe disease, antiphospholipid antibodies (APA) are not known to be a common occurrence. We describe a child with severe acute kidney injury who was noted to have prolonged positivity of both ANCA and APA; a renal biopsy showed noncrescentic immune complex mediated glomerulonephritis with subepithelial deposits compatible with PIGN. He recovered without maintenance immunosuppressive therapy and at last follow-up had normal renal function. We discuss the cooccurrence and implications of ANCA and APA in children with PIGN.