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Case Reports in Medicine
Volume 2018, Article ID 2840707, 4 pages
https://doi.org/10.1155/2018/2840707
Case Report

Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis

1Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence should be addressed to Omid Reza Zekavat; moc.liamg@tavakezo

Received 16 October 2017; Revised 27 December 2017; Accepted 2 January 2018; Published 31 January 2018

Academic Editor: Thomas R. Chauncey

Copyright © 2018 Ali Amanati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cytomegalovirus (CMV) retinitis is one of the rare but debilitating presentations of the CMV infection in children with leukemia. Herein, we report a 12-year-old boy with acute myeloid leukemia complicated by rapid progressive visual loss during relapse of leukemia. The definite diagnosis of CMV retinitis was made after vitreous aspiration. Despite prompt treatment and ophthalmologic intervention, he died because of AML relapse. Viral infections, especially cytomegalovirus infection, may present with vague clinical pictures during any time of chemotherapy, which may not be easily distinguishable from bacterial or fungal retinitis and also chemotherapy-induced retinopathies. Clinician should consider CMV retinitis in seropositive patients especially those without detectable viremia.