Case Report

Bortezomib-Induced Pulmonary Toxicity: A Case Report and Review of Literature

Table 2

Outcome based on individual categorical variables: sex, new/relapsed/refractory type, prior SCT, smoking, previous lung injury, steroid just prior to BTZ, and concurrent chemotherapy ().

VariableOutcome value
Death (%)Resolution of BLI (%)

SexFemale6 (50)6 (50)0.2555
Male7 (30)16 (70)

Type of BLINew3 (33)6 (67)0.8450
Relapsed7 (37)12 (63)
Refractory2 (50)2 (50)

Prior SCTNo2 (11)16 (89)0.0360
Yes5 (45)6 (55)

SmokingNo6 (35)11 (65)0.1193
Yes0 (0)5 (100)

Previous lung injuriesNo10 (50)10 (50)0.4726
Yes2 (33)4 (67)

Prior or concurrent steroidsNo10 (34)19 (66)0.8116
Yes2 (40)3 (60)

Concurrent chemotherapyNo12 (41)17 (59)0.3636
Yes1 (20)4 (80)

Chi-square test.